Job Title: Senior Associate Scientist, Discovery

Work Location: Middlesex County, MA

Summary:

Seeking a Senior Associate Scientist to support routine and scalable testing of discovery compounds in cell-based cytosolic exposure (CE) assay workflows. This is a contract position with a focus on executing and optimizing cellular assays to advance next-generation molecules.

Responsibilities:

• Conduct daily CE assay testing for discovery compounds, including all steps from cell seeding to endpoint measurement and primary quality control.
• Ensure consistent assay performance by utilizing controls, reference standards, and monitoring key metrics for quality assurance.
• Support compound testing workflows to enable rapid iteration of structure–activity relationships in collaboration with scientific teams.
• Compile, organize, and present assay data for team discussions, clearly communicating results and any observed anomalies.
• Identify and troubleshoot technical issues related to cell health, reagent performance, and equipment, implementing process improvements as needed.
• Assist with reagent qualification, robustness checks, and method transfers among team members and equipment.
• Maintain laboratory spaces and equipment, manage inventory, and prepare routine buffers, media, and reagents.
• Collaborate with cross-functional teams in chemistry, biology, and data science to ensure timely and high-quality data delivery.

Qualifications:

• B.S. in Biology, Biochemistry, Molecular Biology, Bioengineering, or related field with approximately 6+ years of relevant industry experience; or M.S. with approximately 3+ years of relevant experience.
• Hands-on experience with mammalian cell culture and sterile technique.
• Proficiency in executing plate-based assays, including multichannel pipetting and/or liquid handling.
• Strong attention to detail, data quality, and consistent documentation; ability to work according to SOPs and timelines.
• Effective communication skills and ability to work collaboratively in an on-site, cross-functional environment.
• Experience supporting or running liquid chromatography-mass spectrometry (LC-MS) assays, including sample preparation and data interpretation.
• Familiarity with cell-based uptake/trafficking measurements, such as fractionation workflows or confocal microscopy support.
• Experience with proximity-dependent cellular readouts (e.g., NanoBiT/NanoBRET) or other CE/uptake-enabled assay formats.
• Background in oncology and/or peptide modalities is a plus.
• Experience with automation (liquid handlers), high-throughput assay operations, and assay QC statistics is preferred.

Published Category: Discovery Research & Preclinical