Job Title: Scientist Discovery Science

Work Location: New York County, New York

Summary:

This role focuses on advancing discovery science initiatives, particularly in oncology, through the design and execution of experimental plans, development of assays, and collaboration with cross-functional teams. The position requires significant in vivo and translational biomarker experience, as well as strong communication and project management skills.

Responsibilities:

• Design and implement experimental plans for discovery projects, guiding efforts from target validation to early pharmacology.
• Utilize genetic perturbation techniques such as CRISPR/Cas9 and RNAi, and conduct pathway mapping and combination studies relevant to chromosomal instability biology.
• Develop and optimize cellular assays to assess phenotypic and mechanistic outcomes.
• Create and refine target engagement and pharmacodynamic assays to support structure-activity relationship studies and inform dose/PK–PD modeling in in vivo settings.
• Manage external research collaborations, overseeing projects from initial scoping to final data delivery.
• Collaborate with internal teams to contribute to adjacent discovery-related initiatives and ensure project alignment.
• Communicate project updates to various stakeholders, prepare technical reports, support intellectual property filings, and assemble data packages for key milestones.
• Apply in vivo oncology expertise, including mouse model work, to support translational research and biomarker development.

Qualifications:

• PhD in Molecular/Cell Biology, Biochemistry, Cancer Biology, Pharmacology, or a related field; or MS/BS with equivalent industry experience.
• Minimum of 5 years of hands-on laboratory experience with cell-based assays and molecular biology techniques; strong preference for in vivo mouse model experience.
• Familiarity with the drug development process from target identification through to marketing authorization.
• Demonstrated ability to manage external research projects and collaborations.
• Excellent communication, organizational, and problem-solving abilities.
• Proven ability to work collaboratively within multidisciplinary teams.
• Experience in chromosomal instability biology (mitosis, microtubules/kinetochore function, replication stress, DNA damage response) or image-based phenotyping is highly valued.
• Knowledge of in vivo oncology models (xenograft/PDX, syngeneic), PK/PD concepts, and translational biomarker strategies is preferred.

Published Category: Discovery Research & Preclinical