Job Title: Principal / Senior Scientist, Biologics Innovation

Work Location: Middlesex County, Massachusetts

Summary:

Lead the advancement of multi-specific biologics for extracellular protein degradation in autoimmune research. This position is highly technical and hands-on, requiring expertise in biologics design, cell-based assay development, and rapid experimental execution to drive programs from concept through lead optimization.

Responsibilities:

• Lead the design and biological evaluation of bispecific antibodies and extracellular degraders targeting scavenger receptor pathways.
• Develop and implement advanced cell-based assays to demonstrate targeted protein degradation, including monitoring internalization and lysosomal trafficking.
• Construct and utilize novel cell lines, including knock-in and knock-out models, to validate therapeutic windows of degrader candidates versus traditional inhibitors.
• Apply multi-color flow cytometry and high-content imaging to analyze protein turnover, drug recycling, and surface expression dynamics in real time.
• Conduct rapid "quick-kill" experiments to prioritize molecular architectures under tight project timelines.
• Collaborate with protein engineers to optimize linker design, geometry, and affinity for bispecifics and degraders.
• Utilize binding kinetics techniques (SPR/BLI) to characterize multi-valent interactions and inform biologic design.
• Quantify protein reduction using flow cytometry and ELISA/MSD, and interpret degradation kinetics versus binding effects.

Qualifications:

• Ph.D. in Immunology or a related field.
• 5–8+ years of industry experience focused on complex biologics in fast-paced environments.
• Proven experience designing bispecifics and understanding multi-specific formats, including bridging assays and dual-target engagement.
• Expertise in binding kinetics (SPR/BLI) for multi-valent interactions.
• Proficiency in flow cytometry and ELISA/MSD for protein quantification.
• Demonstrated ability to collaborate on linker, geometry, and affinity-tuning for bispecifics and degraders.
• Hands-on experience with extracellular protein degradation or targeted protein trafficking.
• Strong communication skills to explain degradation kinetics versus binding.

Published Category: Discovery Research & Preclinical