Job Title: Senior Research Associate – Bioconjugation / ADC Development (Contractor)

Work Location: Grafton County, NH

Summary:

Seeking a skilled Senior Research Associate with expertise in bioconjugation and in vitro assays to support the development of antibody-targeted siRNA/ASO therapeutics for chronic inflammatory and autoimmune diseases. This is a 6-to-9 month on-site contractor position, offering the chance to make significant scientific contributions in a fast-paced environment.

Responsibilities:

• Lead bioconjugation, purification, and characterization of biologics, including antibodies and oligonucleotides.
• Optimize and troubleshoot purification processes using affinity, ion-exchange, hydrophobic interaction, and size exclusion chromatography, as well as tangential flow filtration.
• Perform buffer exchange and concentration processes for biologics and conjugates.
• Conduct comprehensive analytical characterization of antibody drug conjugates using UV-Vis, SEC, HIC, RP-HPLC, and IEX methods.
• Support formulation development and stability studies for antibody and oligonucleotide conjugates.
• Execute in vitro assays, including ELISA, RNA isolation, and cell-based assays, to evaluate candidate molecules.
• Collaborate with internal teams and external partners to advance research project goals.
• Maintain accurate documentation, ensure data integrity, and contribute to a collaborative and dynamic work environment.

Qualifications:

• MS degree in biochemistry, chemistry, or related field with at least 4 years of relevant experience.
• Hands-on experience in bioconjugation, conjugate purification, and characterization.
• Proficiency with AKTA Pure FPLC systems and Agilent 1260 HPLC.
• Expertise in buffer exchange and concentration techniques.
• Experience executing in vitro assays such as ELISA, RNA isolation, and cell-based assays.
• Background in ADC/AOC formulation and stability studies is preferred.
• Strong problem-solving skills, scientific curiosity, and ability to work independently in a fast-paced environment.
• Excellent communication, organizational, and interpersonal skills, with a collaborative and goal-oriented approach.

Published Category: Discovery Research & Preclinical