Work Location: Middlesex County, Massachusetts

Summary:

Seeking a skilled scientist to design, execute, and analyze cell-based assays and high-throughput screening workflows, contributing to the advancement of genomic engineering platforms and programs. This role requires strong technical expertise, data analysis skills, and the ability to collaborate within cross-functional teams.

Responsibilities:

• Design and implement cell-based assays and screening workflows to support platform and program goals, both independently and collaboratively.
• Develop and execute high-throughput arrayed and pooled screening campaigns with a focus on rigor and reproducibility.
• Troubleshoot experimental protocols, analyze data, and translate findings into actionable scientific insights.
• Maintain comprehensive and accurate laboratory records, ensuring clear communication of data and results to scientific teams.
• Collaborate with cross-functional partners to advance optimized candidates into translational and preclinical development stages.
• Utilize gene editing technologies, such as CRISPR nucleases, recombinases, base editors, or transcriptional effectors, in experimental workflows.
• Apply laboratory automation platforms to enhance efficiency and consistency in cell-based screening processes.
• Present complex technical information clearly to diverse audiences and manage multiple projects and datasets with strong organizational skills.

Qualifications:

• Bachelor’s degree in cell biology, molecular biology, or a related field with 5+ years of relevant experience, or a Master’s degree with 3+ years of experience.
• Experience conducting high-throughput cell-based screens; expertise with primary T cells, hepatocytes, and cancer cell lines preferred.
• Hands-on experience with gene editing technologies, including CRISPR nucleases, recombinases, base editors, or transcriptional effectors.
• Familiarity with laboratory automation platforms for cell-based screening workflows.
• Proficiency in nucleic acid quality control methods such as TapeStation, Qubit, NanoDrop, and qPCR.
• Demonstrated ability to independently generate precise, reproducible data and perform rigorous quantitative analysis.
• Strong collaborative mindset and team-first approach.
• Excellent written and verbal communication skills, with the ability to present technical information clearly and concisely.
• Exceptional organizational skills, capable of managing complex datasets and multiple overlapping projects.

Published Category: Discovery Research & Preclinical